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Spyre Therapeutics Inc. (SYRE)

US · Healthcare · Biotechnology

$92.68+1.66%
Last close · 2026-09-17

Latest quarter · ended 2026-06-30

Revenue
$0
Net profit
$-36.2M
EPS
$-0.36
EPS estimate
$-0.71

EPS came in at -0.36 against a street estimate of -0.71 — a beat of 49.3%.

Key statistics

Market cap
$7.87B
Forward P/E
0.0
P/B
8.37
Book value
$10.84
EPS (TTM)
$-1.92
52-week high
$110.17
52-week low
$14.51
50-day MA
$98.10
200-day MA
$63.29
Beta
3.00

Analyst view

Analysts rate Spyre Therapeutics Inc. a strong buy (10 buy, 1 hold, 0 sell out of 11) with an average price target of $120.08.

Shareholding

Insiders
5.70%
Institutions
110.62%

Largest institutional holders

FundStake
FMR Inc13.36%
BlackRock Inc6.26%
Perceptive Advisors LLC4.90%
RTW INVESTMENTS, LLC4.73%
Fairmount Funds Management LLC4.56%
Paradigm Biocapital Advisors LP4.36%
VR Adviser, LLC4.18%
Vanguard Capital Management, LLC3.47%

Recent filings & reports

DocumentDate
Reg FD disclosure · Q3 2026
SPYRE THERAPEUTICS, INC. - DOCUMENT SUMMARY HEADLINE NUMBERS • SPY003 Primary Endpoint Met: 10.0-point reduction in Robarts Histopathology Index (RH
2026-09-08
Reg FD disclosure · Q3 2026
SPYRE THERAPEUTICS, INC. – DOCUMENT SUMMARY HEADLINE NUMBERS • SPY072 Low Dose: -1.9 point change in DAS28-CRP at Week 12 (statistically significant
2026-08-25
Quarterly report · Q2 2026
SPYRE THERAPEUTICS, INC. – Q2 2026 10-Q SUMMARY HEADLINE NUMBERS • Cash and marketable securities: $1,145.3 million as of June 30, 2026 (up from $75
2026-08-04
Results announced · Q3 2026
SPYRE THERAPEUTICS Q2 2026 FINANCIAL RESULTS SUMMARY HEADLINE NUMBERS • Cash position of $1,145.3 million ($162.0 million cash + $983.3 million mark
2026-08-04
Reg FD disclosure · Q2 2026
SPYRE THERAPEUTICS, INC. – FORM 8-K SUMMARY Date of Report: June 15, 2026 --- HEADLINE NUMBERS • Primary Endpoint Met: SPY002 achieved a statistica
2026-06-15
Quarterly report · Q1 2026
SPYRE THERAPEUTICS, INC. - Q1 2026 SUMMARY HEADLINE NUMBERS • Cash Position: $97.2 million cash + $644.3 million marketable securities = $741.5 mill
2026-05-05
Proxy statement · Q2 2026
SPYRE THERAPEUTICS, INC. — 2026 PROXY STATEMENT SUMMARY --- CEO COMPENSATION & CHANGE • Cameron Turtle (CEO) total compensation: Not explicitly sta
2026-04-10
Annual report FY2025
SPYRE THERAPEUTICS, INC. - 10-K SUMMARY FOR RETAIL INVESTORS HEADLINE NUMBERS • Market capitalization as of June 30, 2025: approximately $1.1 billio
2026-02-19

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Deals & corporate news

AnnouncementDate
Expanded license agreement field of use with Paragon Therapeutics
Spyre Therapeutics expanded the commercial rights to its SPY003 drug candidate on May 29, 2026. Originally limited to inflammatory bowel disease (IBD), the company can now pursue SPY003 in a
2026-06-01

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Data updated 2026-09-18.