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Rhythm Pharmaceuticals Inc (RYTM)

US · Healthcare · Biotechnology

$99.02+1.03%
Last close · 2026-09-17

Latest quarter · ended 2026-06-30

Revenue
$71.3M
Revenue YoY
+46.9%
Net profit
$-49.3M
EPS
$-0.73
EPS estimate
$-0.81
Net margin
-69.2%

EPS came in at -0.73 against a street estimate of -0.81 — a beat of 9.9%.

Key statistics

Market cap
$7.21B
Forward P/E
555.6
P/B
70.08
Book value
$1.50
EPS (TTM)
$-3.12
52-week high
$122.20
52-week low
$74.50
50-day MA
$108.88
200-day MA
$99.61
Beta
1.97

Analyst view

Analysts rate Rhythm Pharmaceuticals Inc a strong buy (12 buy, 0 hold, 0 sell out of 12) with an average price target of $140.19.

From the latest earnings call · 2026-08-04

CONFIDENT Strong HO launch with 400+ start forms in 14 weeks; RM-718 shows comparable efficacy to setmelanotide with no hyperpigmentation; Q2 revenue $71.3M (+47% YoY); cash position $331M supports 24+ months operations. Q2 2026 International revenue declined Q2 vs Q1 due to $3.8M French contribution mechanism charge (mostly 2025-related). Europe HO launches anticipated in 2027 starting Germany H1; Japan approval and launch expected by year-end 2026. Analysts probed launch sustainability (no bolus evident), HO vs. BBS discontinuation rates (HO lower expected), PWS asset choice (CMC-driven, both possible), and GLP-1 competition (50% prior exposure, different mechanism). Management emphasized precision medicine positioning, breadth metrics, and multi-asset optionality rather than single-drug strategy. 2026-08-04…

Full summary in the app.

Shareholding

Insiders
0.70%
Institutions
114.78%

Largest institutional holders

FundStake
RA Capital Management, LLC9.68%
BlackRock Inc9.06%
Baker Bros Advisors LP8.14%
PRIMECAP Management Company4.60%
Vanguard Portfolio Management, LLC4.42%
Vanguard Capital Management, LLC4.31%
Perceptive Advisors LLC3.76%
State Street Corp3.30%

Recent filings & reports

DocumentDate
Quarterly report · Q2 2026
RHYTHM PHARMACEUTICALS, INC. – FORM 10-Q SUMMARY For Quarter Ended June 30, 2026 --- HEADLINE NUMBERS • Product Revenue (6 months 2026): $131.4 mil
2026-08-04
Results announced · Q3 2026
RHYTHM PHARMACEUTICALS Q2 2026 EARNINGS SUMMARY HEADLINE NUMBERS • Q2 2026 product revenue: $71.3 million (up 19% sequentially from Q1 2026; up 47%
2026-08-04
Shareholder vote results · Q2 2026
RHYTHM PHARMACEUTICALS, INC. - FORM 8-K SUMMARY HEADLINE NUMBERS • Annual Meeting held June 24, 2026 • 68,530,107 shares of common stock outstanding
2026-06-25
Reg FD disclosure · Q2 2026
RHYTHM PHARMACEUTICALS, INC. – FORM 8-K SUMMARY HEADLINE NUMBERS • Prader-Willi Syndrome (PWS) Phase 2 Trial – 6-Month Interim Data: - 18 patients
2026-06-15
Quarterly report · Q1 2026
RHYTHM PHARMACEUTICALS, INC. - Q1 2026 10-Q SUMMARY HEADLINE NUMBERS • Cash & Short-term Investments: $340.6 million as of March 31, 2026 ($62.1 mil
2026-05-05
Results announced · Q2 2026
RHYTHM PHARMACEUTICALS Q1 2026 FINANCIAL SUMMARY HEADLINE NUMBERS • Q1 2026 Product Revenue: $60.1 million (up 5% sequentially from Q4 2025; up 59%
2026-05-05
Proxy statement · Q2 2026
RHYTHM PHARMACEUTICALS, INC. – PROXY STATEMENT SUMMARY --- CEO COMPENSATION & CHANGES • David P. Meeker, M.D. (Chairman, President, and CEO) – Tota
2026-04-29
Annual report FY2025
RHYTHM PHARMACEUTICALS, INC. – FORM 10-K SUMMARY Fiscal Year Ended December 31, 2025 --- HEADLINE NUMBERS • Total product sales to date: Approximat
2026-02-26

Readable in the app.

Deals & corporate news

AnnouncementDate
FDA Approval of IMCIVREE for Acquired Hypothalamic Obesity
Rhythm Pharmaceuticals announced FDA approval of IMCIVREE (setmelanotide) for treating acquired hypothalamic obesity (AHO), a rare disease causing severe weight gain from hypothalamic injury
2026-03-20

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Data updated 2026-09-18.