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Denali Therapeutics Inc (DNLI)

US · Healthcare · Biotechnology

$20.13+0.35%
Last close · 2026-09-17

Latest quarter · ended 2026-06-30

Revenue
$3.6M
Net profit
$-127.6M
EPS
$-0.68
EPS estimate
$-0.72
Net margin
-3,539.2%

EPS came in at -0.68 against a street estimate of -0.72 — a beat of 5.6%.

Key statistics

Market cap
$3.21B
Forward P/E
0.0
P/B
3.90
Book value
$5.23
EPS (TTM)
$-2.79
52-week high
$27.30
52-week low
$12.58
50-day MA
$23.89
200-day MA
$20.94
Beta
1.00

Analyst view

Analysts rate Denali Therapeutics Inc a strong buy (19 buy, 0 hold, 0 sell out of 19) with an average price target of $36.06.

From the latest earnings call · 2026-08-06

CONFIDENT AVLAYAH launched stronger than expected with $3.6M Q2 revenue and >50% payer coverage. Guidance raised to $10–12M Q3. Two Alzheimer's programs entered clinic. Pro forma cash $1.1B post-PRV sale. Q2 2026 No regional breakdown provided in call. Analysts pressed on bolus vs. sustainable growth, CNS distribution comparisons to intrathecal competitors, and biomarker expectations for tau program. Management acknowledged early demand exceeded forecast but emphasized expanding adoption to broader population and differentiation via even IV-delivered biodistribution vs. patchy intrathecal delivery. 2026-08-06…

Full summary in the app.

Shareholding

Insiders
9.08%
Institutions
101.32%

Largest institutional holders

FundStake
BlackRock Inc8.15%
Baillie Gifford & Co Limited.7.48%
T. Rowe Price Investment Management,Inc.5.33%
Temasek Holdings Ltd.4.39%
State Street Corp3.92%
Vanguard Capital Management, LLC3.85%
Vanguard Portfolio Management, LLC3.83%
FMR Inc2.86%

Recent filings & reports

DocumentDate
Quarterly report · Q2 2026
DENALI THERAPEUTICS INC. — FORM 10-Q SUMMARY Quarter Ended June 30, 2026 --- HEADLINE NUMBERS • Cash and marketable securities combined: $940.0 mil
2026-08-06
Results announced · Q3 2026
DENALI THERAPEUTICS Q2 2026 FINANCIAL RESULTS SUMMARY HEADLINE NUMBERS • Q2 2026 net product revenue: $3.6 million (first full quarter of AVLAYAH co
2026-08-06
Acquisition completed · Q3 2026
DENALI THERAPEUTICS INC. - FORM 8-K SUMMARY HEADLINE NUMBERS • Company completed sale of Rare Pediatric Disease Priority Review Voucher (PRV) on Jul
2026-07-28
Material agreement · Q2 2026
DENALI THERAPEUTICS INC. - FORM 8-K SUMMARY HEADLINE NUMBERS • Company agreed to sell its Rare Pediatric Disease Priority Review Voucher (PRV) for $
2026-06-18
Shareholder vote results · Q2 2026
DENALI THERAPEUTICS INC. - 8-K SUMMARY HEADLINE NUMBERS • 158,675,498 shares of common stock outstanding as of April 9, 2026 (record date) • 137,986
2026-06-04
Quarterly report · Q1 2026
DENALI THERAPEUTICS INC. — Q1 2026 10-Q SUMMARY HEADLINE NUMBERS • Cash position: $387.6 million in cash and cash equivalents as of March 31, 2026 (
2026-05-07
Proxy statement · Q4 2025
DENALI THERAPEUTICS INC. — 2026 PROXY STATEMENT SUMMARY CEO COMPENSATION • Ryan J. Watts (President and Chief Executive Officer) total compensation:
2026-04-21
Annual report FY2025
DENALI THERAPEUTICS INC. – FORM 10-K SUMMARY FOR RETAIL INVESTORS HEADLINE NUMBERS • Market cap as of June 30, 2025: approximately $1.1 billion (bas
2026-02-26

Readable in the app.

Deals & corporate news

AnnouncementDate
2026 Outlook Press Release Filed
Denali Therapeutics filed an 8-K on January 6, 2026 to disclose a 2026 Outlook press release. The filing itself contains minimal substantive information—it consists primarily of standard SEC
2026-01-06

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Data updated 2026-09-18.