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Alnylam Pharmaceuticals Inc (ALNY)

US · Healthcare · Biotechnology

$245.51+2.57%
Last close · 2026-09-17

Latest quarter · ended 2026-06-30

Revenue
$1.29B
Revenue YoY
+66.9%
Net profit
$164.5M
EPS
$1.21
EPS estimate
$1.44
Net margin
12.7%

EPS came in at 1.21 against a street estimate of 1.44 — a miss of 16.0%.

Key statistics

Market cap
$33.28B
P/E
43.3
Forward P/E
19.5
P/B
24.57
Book value
$10.12
EPS (TTM)
$5.74
52-week high
$495.55
52-week low
$197.81
50-day MA
$255.36
200-day MA
$317.18
Beta
0.30

Analyst view

Analysts rate Alnylam Pharmaceuticals Inc a buy (22 buy, 8 hold, 0 sell out of 30) with an average price target of $371.35.

From the latest earnings call · 2026-07-30

MIXED AMVUTRA hit $1B+ quarterly revenue in rare disease launch, but Alnylam cut full-year guidance $200M citing normalized second-line demand. First-line momentum and favorable competitor exits support confidence in 2030 goals. Q2 2026 New Ben Pharma partnership announced for exclusive AMVUTRA commercialization rights in Mainland China and Hong Kong, subject to regulatory approval. Europe growing modestly due to price adjustments ahead of tafamidis generics. Analysts pressed on guidance cut mechanics, combo therapy payer pushback post-CARDIO-TTRansform, and TRITON-CM protocol flexibility. Management emphasized first-line durability, intact access, and confidence in nucrisiran's superior knockdown profile. 2026-07-30…

Full summary in the app.

Shareholding

Insiders
0.18%
Institutions
101.61%

Largest institutional holders

FundStake
FMR Inc10.90%
Capital World Investors8.33%
BlackRock Inc7.81%
Capital Research Global Investors7.29%
Vanguard Portfolio Management, LLC4.85%
JPMorgan Chase & Co4.73%
Vanguard Capital Management, LLC4.44%
T. Rowe Price Investment Management,Inc.3.88%

Recent filings & reports

DocumentDate
Quarterly report · Q2 2026
ALNYLAM PHARMACEUTICALS, INC. – FORM 10-Q SUMMARY Quarter Ended June 30, 2026 --- HEADLINE NUMBERS • Net product revenues (Q2 2026): $1,172,109 tho
2026-07-30
Results announced · Q3 2026
ALNYLAM PHARMACEUTICALS Q2 2026 EARNINGS SUMMARY HEADLINE NUMBERS • Q2 2026 Global Net Product Revenues: $1,172 million (74% growth vs Q2 2025) • To
2026-07-30
Board / officer change · Q2 2026
ALNYLAM PHARMACEUTICALS, INC. – FORM 8-K SUMMARY HEADLINE NUMBERS • Board expanded from 10 to 11 directors effective June 1, 2026 • 133,427,910 shar
2026-05-27
Quarterly report · Q1 2026
ALNYLAM PHARMACEUTICALS, INC. – Q1 2026 10-Q SUMMARY HEADLINE NUMBERS • Total revenues (Q1 2026): $1,167.2 million vs. $594.2 million (Q1 2025) — in
2026-04-30
Results announced · Q2 2026
ALNYLAM PHARMACEUTICALS Q1 2026 EARNINGS SUMMARY HEADLINE NUMBERS • Q1 2026 total net product revenues: $1,036 million (121% growth vs. Q1 2025) • Q
2026-04-30
Proxy statement · Q2 2026
ALNYLAM PHARMACEUTICALS (ALNY) – 2026 PROXY SUMMARY WHAT SHAREHOLDERS ARE VOTING ON • Proposal 1: Elect three Class I directors to serve until 2029:
2026-04-06
Board / officer change · Q1 2026
ALNYLAM PHARMACEUTICALS, INC. – FORM 8-K SUMMARY HEADLINE NUMBERS • CEO Yvonne Greenstreet granted special performance-based equity award on March 2
2026-03-04
Annual report FY2025
ALNYLAM PHARMACEUTICALS, INC. — 10-K SUMMARY HEADLINE NUMBERS • Market capitalization: approximately $42.63 billion as of June 30, 2025 • Shares out
2026-02-12

Readable in the app.

Deals & corporate news

AnnouncementDate
2025 preliminary results and 2026 combined net product revenue guidance provided
Alnylam Pharmaceuticals announced strong 2025 preliminary revenues and unveiled a new five-year strategic plan called 'Alnylam 2030.' The company reported approximately $2.987 billion in ful
2026-01-12

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Data updated 2026-09-18.